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June 1, 1981Journal of Applied Physiology

Effect of functional overload on substrate oxidation capacity of skeletal muscle

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Authors

KBK. M. BaldwinVVVictor Baylon ValdezLSLars Schrader

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Overview

Randomized trial examines substrate oxidation changes in rodent skeletal muscle due to overload, suggesting muscle type influences oxidative capacity.

Key Points

  • This research investigates how surgically induced functional overload affects the oxidative capacity of different skeletal muscle types in rodents.
  • Evaluated fast-twitch plantaris (P) and slow-twitch soleus (S) muscles in a rodent model.
  • Measured muscle weight, protein concentrations, and enzymatic capacities of oxidative substrates.
  • Compared findings to normal control muscles.
  • Functional overload increased muscle weight by 68% in P muscles and 23% in S muscles (p < 0.05).
  • Oxidative enzyme markers were unchanged in P muscles, but citrate synthase activity decreased overall and in the red region.
  • Soleus muscle showed significant decreases in oxidative capacity relative to controls (p < 0.05).

Cite This Study

Baldwin et al. (1981) studied this question.

synapsesocial.com/papers/6a2194d7fe297d9d92f1c401https://doi.org/10.1152/jappl.1981.50.6.1272
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Also Consider

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