Key result
Endurance running drives fast-to-slower myosin transformations in rodent skeletal muscles.
Why the study?
Little information is available concerning the impact of endurance training on skeletal muscle isomyosin expression across a variety of muscle fiber types.
Population
Rodents undergoing endurance training or nontrained controls
Comparison
Endurance trained vs nontrained rodents
Design
10-week running program experimental study
Follow-up
10 weeks
Authors
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Warrants caution extrapolating rodent myosin shifts to patients; leaves open human skeletal muscle adaptations to endurance training.
p-value: p=<0.05
Fitzsimons et al. (1990) studied this question. Endurance exercise (running program) vs. Nontrained controls was evaluated on Isomyosin expression in skeletal muscle fiber types (p=<0.05). A 10-week endurance running program in rodents elicited fast-to-slower myosin transformations in multiple skeletal muscles, including significant reductions in the fast myosin 2 isoform (P<0.05).
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