Key result
High-resistance training elevates fast type IIX MHC mRNA expression ~250% with just ten contractions.
Population
Red and white medial gastrocnemius muscles
Comparison
High-resistance training regimens
Follow-up
16 days
Authors
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Does not support changes to human training regimens; leaves open whether minimal contractions modulate MHC isoforms in clinical populations.
High-resistance training is a powerful modulator of MHC protein isoforms, with pretranslational mechanisms sensitive to even small amounts of training.
Caiozzo et al. (1996) studied this question. High-resistance training was evaluated on Myosin heavy-chain (MHC) protein and mRNA isoform expression. High-resistance training elevated fast type IIX MHC mRNA isoform expression by approximately 250% with as few as 10 contractions per session.
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