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January 28, 2005Journal of Applied Physiology

Effects of resistance training on myosin function studied by the in vitro motility assay in young and older men

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Why the study?

Does a 12-week progressive resistance training program change the velocity of sliding of actin filaments on pure myosin isoforms in young and older men?

Population

8 men, comprising 4 young (age 23-29 yr) and 4 elderly (age 68-82 yr)

Comparison

12-week progressive resistance training program… vs Pre-training baseline

Design

Other

Follow-up

12 weeks

Authors

MCMonica CanepariRRR. RossiMPMaria Antonietta Pellegrino

Discussion

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Overview

Resistance training may enhance myosin velocity in young and older men; leaves open clinical translation and mechanisms.

Structured PICO

Does a 12-week progressive resistance training program change the velocity of sliding of actin filaments on pure myosin isoforms in young and older men?

P
Population
8 men, comprising 4 young (age 23-29 yr) and 4 elderly (age 68-82 yr)
I
Intervention
12-week progressive resistance training program of the knee extensor muscles
C
Comparator
Pre-training baseline
O
Outcome
Velocity of sliding (V(f)) of actin filaments on pure myosin isoforms extracted from single fibers in in vitro motility assaysurrogate

Resistance training can increase the velocity of the myosin molecule without a change in isoform composition in both young and older men.

Cite This Study

Canepari et al. (2005) studied this question.

synapsesocial.com/papers/6a1fd7d9f9974f87113e660dhttps://doi.org/10.1152/japplphysiol.01103.2004
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