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June 1, 1987Journal of Applied Physiology

Normalized plantaris weight was greater in the overload group compared with the overload-suspension group by 35% (P < 0.001), with a significant increase in slow and intermediate myosin expression in the overload group.

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Population

Female rats (n=28, 4 groups of n=7)

Comparison

Functional overload and/or hindlimb unweighting… vs Normal-control (NC) group

Design

Preclinical

Follow-up

6 weeks

Authors

RTR. W. TsikaRHR. E. HerrickKBK. M. Baldwin

Discussion

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Overview

Supports weight-bearing necessity in rodent overload models; leaves open translation to human muscle adaptation.

Structured PICO

P
Population
Female rats (n=28, 4 groups of n=7)
I
Intervention
Functional overload (induced via synergist removal) and/or hindlimb unweighting (suspension) for 6 weeks
C
Comparator
Normal-control (NC) group
O
Outcome
Compensatory muscle growth (normalized plantaris weight) and changes in myosin isoform expressionsurrogate

Weight bearing is an essential component of the overload model for inducing significant increases in both muscle mass and slow myosin isoform expression in rodent fast-twitch plantaris muscle.

Cite This Study

Tsika et al. (1987) studied this question.

synapsesocial.com/papers/6a8d030b8a9f77207c301f85https://doi.org/10.1152/jappl.1987.62.6.2180
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