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July 1, 1990Journal of Applied Physiology

Peak oxygen consumption was not different between CAP (5.34 +/- 0.55 mumols.min-1.g-1) and control (5.74 +/- 0.43) groups.

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Why the study?

Does chloramphenicol-induced reduction in electron transport capacity impair peak oxygen consumption and muscle performance in rat skeletal muscle?

Population

Isolated rat hindlimb preparation (n=13)

Comparison

Chloramphenicol treatment for 10-14 days to… vs Control rat hindlimbs

Design

Preclinical

Follow-up

10-14 days

Authors

RMR. M. McAllisterRORobert W. OgilvieRTRonald L. Terjung

Discussion

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Overview

Preserved peak VO2 despite reduced electron transport in rats; leaves open translational relevance to human mitochondrial myopathies.

Structured PICO

Does chloramphenicol-induced reduction in electron transport capacity impair peak oxygen consumption and muscle performance in rat skeletal muscle?

P
Population
Isolated rat hindlimb preparation (n=13)
I
Intervention
Chloramphenicol (CAP) treatment for 10-14 days to reduce capacity for electron transport
C
Comparator
Control rat hindlimbs
O
Outcome
Peak oxygen consumption and isometric performancesurrogate

Rat skeletal muscle can maintain peak oxygen consumption and performance despite a significant reduction in electron transport capacity.

Cite This Study

McAllister et al. (1990) studied this question.

synapsesocial.com/papers/6a96f57ac00de92d9bfbd9f0https://doi.org/10.1152/jappl.1990.69.1.384
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Acute inhibition of respiratory capacity of muscle reduces peak oxygen consumption1990 · 79 citations
  2. 2Oxidative capacity interacts with oxygen delivery to determine maximal O2 uptake in rat skeletal muscles in situ2002 · 37 citations
  3. 3Effect of gradual reduction in O2 delivery on intracellular homeostasis in contracting skeletal muscle1996 · 70 citations
  4. 4Effects of muscle contraction on cytochrome a,a3 redox state1993 · 34 citations
  5. 5Aerobic power declines with aging in rat skeletal muscles perfused at matched convective O2 delivery2003 · 61 citations