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June 1, 2002The Journal of PhysiologyOpen Access

Oxidative capacity interacts with oxygen delivery to determine maximal O2 uptake in rat skeletal muscles in situ

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Population

Pump-perfused rat hindlimb model (four groups of animals)

Comparison

0.1 microM myxothiazol combined with moderately… vs High O2 delivery (88 +/- 1 micromol O2 min)…

Design

Preclinical

Authors

RHRussell T. HeppleJHJason L. HagenDKDan J. Krause

Discussion

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Overview

Supports O2 supply-mitochondrial interaction limiting VO2max; extends animal models but leaves open human translation.

Structured PICO

P
Population
Pump-perfused rat hindlimb model (four groups of animals)
I
Intervention
0.1 microM myxothiazol combined with moderately reduced O2 delivery (66 +/- 2 micromol O2 min(-1))
C
Comparator
High O2 delivery (88 +/- 1 micromol O2 min(-1)) without myxothiazol, high O2 delivery with myxothiazol, and moderately reduced O2 delivery without myxothiazol
O
Outcome
Maximal O2 uptake (V(O2)max)surrogate

Oxygen supply and mitochondrial oxidative capacity interact to determine maximal oxygen uptake in skeletal muscle.

Cite This Study

Hepple et al. (2002) studied this question.

synapsesocial.com/papers/6a70464bac440176ef28ed0ahttps://doi.org/10.1113/jphysiol.2001.013649
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Gas exchange and peripheral diffusion limitation1992 · 127 citations
  2. 2Evidence of O<sub>2</sub> supply-dependentV˙<scp>o</scp> <sub>2 max</sub> in the exercise-trained human quadriceps1999 · 231 citations
  3. 3Increased peak oxygen consumption of trained muscle requires increased electron flux capacity1994 · 65 citations
  4. 4Effects of hyperoxia on maximal leg O2 supply and utilization in men1993 · 232 citations
  5. 5Blood flow distribution in tissues of perfused rat hindlimb preparations1986 · 56 citations