August 1, 1993Journal of Applied Physiology

The concentration of oxidized mitochondrial cytochrome a,a3 decreased at all work loads relative to resting state and demonstrated a near-linear relationship with muscle VO2 (r2 = 0.99).

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Population

20 adult dogs, anesthetized with alpha-chloralose, intubated, and mechanically ventilated on room air

Comparison

5-minute electrical stimulation periods at rates… vs Resting state

Design

Preclinical

Authors

FDFrancis G. Duhaylongsod JGJ. A. Griebel DBDouglas Bacon

Discussion

Member takes

Overview

Hypothesis-generating for O2 delivery limiting VO2max in canine muscle; leaves open human translation.

Structured PICO

Population

20 adult dogs, anesthetized with alpha-chloralose, intubated, and mechanically ventilated on room air

Intervention

5-minute electrical stimulation periods at rates of 2, 3, 4, 5, 7, 8, 10, or 12 stimuli/s

Comparator

Resting state

Outcome

Oxidation-reduction state of cytochrome a,a3 monitored by near-infrared spectroscopysurrogate

In canine skeletal muscle, maximal exercise leads to near-complete reduction of cytochrome a,a3, indicating that VO2max is primarily limited by O2 delivery rather than mitochondrial ATP production.

Cite This Study

Duhaylongsod et al. (1993) studied this question.

synapsesocial.com/papers/6a709dfcf44fa9f079de4b45 https://doi.org/10.1152/jappl.1993.75.2.790

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August 1, 1993Journal of Applied Physiology

The concentration of oxidized mitochondrial cytochrome a,a3 decreased at all work loads relative to resting state and demonstrated a near-linear relationship with muscle VO2 (r2 = 0.99).

View Full Paper

Ask AI

Bookmark

Population

20 adult dogs, anesthetized with alpha-chloralose, intubated, and mechanically ventilated on room air

Comparison

5-minute electrical stimulation periods at rates… vs Resting state

Design

Preclinical

Authors

FDFrancis G. Duhaylongsod JGJ. A. Griebel DBDouglas Bacon

Discussion

Member takes

Overview

Hypothesis-generating for O2 delivery limiting VO2max in canine muscle; leaves open human translation.

Structured PICO

Population

20 adult dogs, anesthetized with alpha-chloralose, intubated, and mechanically ventilated on room air

Intervention

5-minute electrical stimulation periods at rates of 2, 3, 4, 5, 7, 8, 10, or 12 stimuli/s

Comparator

Resting state

Outcome

Oxidation-reduction state of cytochrome a,a3 monitored by near-infrared spectroscopysurrogate

In canine skeletal muscle, maximal exercise leads to near-complete reduction of cytochrome a,a3, indicating that VO2max is primarily limited by O2 delivery rather than mitochondrial ATP production.

Cite This Study

Duhaylongsod et al. (1993) studied this question.

synapsesocial.com/papers/6a709dfcf44fa9f079de4b45 https://doi.org/10.1152/jappl.1993.75.2.790

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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