Why the study?
Does gradual reduction in O2 delivery alter intracellular homeostasis in contracting skeletal muscle in a canine model?
Does gradual reduction in O2 delivery alter intracellular homeostasis in contracting skeletal muscle in a canine model?
Gradual reduction of O2 availability in contracting skeletal muscle reduces developed force through tight coupling with aerobic ATP supply without significant disruption of intracellular homeostasis.
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Suggests preserved muscle homeostasis during O2 limitation in canines; leaves open translation to human ischemia or exercise.
Hogan et al. (1996) studied this question.
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