Key result
Slowing blood flow on-kinetics resulted in a linear slowing of the Vo2 on-kinetics response, with average MRT values of 17 s for control, 23 s for 45 s delay, and 26 s for 70 s delay (P<0.05).
Population
Isolated gastrocnemius muscle complex (GS) in situ in six anesthetized dogs
Comparison
Slowing blood flow on-kinetics mean response… vs Control trial with blood flow on-kinetics MRT…
Design
Preclinical
Authors
Loading...
Supports O2 delivery as modulator of muscle VO2 kinetics; leaves open translation to human exercise physiology.
Absolute Event Rate: 26% vs 17%
p-value: p=<0.05
Slowing O2 delivery via slowing blood flow on-kinetics results in a linear slowing of the Vo2 on-kinetics response in isolated canine muscle, suggesting spontaneously perfused skeletal muscle operates at the nexus of sufficient and insufficient O2 delivery during transitions to contractions.
Goodwin et al. (2011) studied this question. Slowing blood flow on-kinetics vs. Control trial with blood flow on-kinetics MRT set at 20 s was evaluated on Vo2 on-kinetics mean response time (MRT) (p=<0.05). Slowing blood flow on-kinetics resulted in a linear slowing of the Vo2 on-kinetics response, with average MRT values of 17 s for control, 23 s for 45 s delay, and 26 s for 70 s delay (P<0.05).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: