Skeletal muscle O2 on-kinetics: set by O2 delivery or by O2 utilization? New insights into an old issue

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Population

Exercising humans and isolated in situ dog gastrocnemius preparation

Design

Review

Authors

Discussion

Supports metabolic inertia as primary limiter of VO2 kinetics; hypothesis-generating for targeted interventions in exercise-limited patients.

Population

Exercising humans and isolated in situ dog gastrocnemius preparation

Intervention

Transitions in exercise intensity (unloaded to loaded pedaling in humans; rest to contractions at approximately 70% peak VO2 in dogs)

Outcome

Limiting factors for skeletal muscle O2 uptake (VO2) on-kineticssurrogate

Skeletal muscle oxygen uptake kinetics during exercise transitions appear to be limited by intrinsic metabolic inertia rather than oxygen delivery.

Bruno Grassi (2000) studied this question.

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Supports metabolic inertia as primary limiter of VO2 kinetics; hypothesis-generating for targeted interventions in exercise-limited patients.