Key result
In silico modeling of canine muscle demonstrated that hyperoxia does not accelerate the dynamics of diffusion and muscle oxygen uptake at contraction onset.
Population
Dog gastrocnemius muscle
Comparison
Hyperoxia vs Different levels of arterial oxygen content and…
Design
Preclinical
Authors
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Challenges expectation that hyperoxia speeds muscle O2 uptake onset; leaves open human in vivo validation of canine modeling.
A mechanistic model demonstrates that hyperoxia does not speed up muscle oxygen uptake dynamics at contraction onset because of increased oxygen stores.
Lai et al. (2007) studied Muscle oxygen uptake dynamics. Hyperoxia vs. Different levels of arterial oxygen content was evaluated on Dynamics of oxygen uptake (Vo2m) at contraction onset. In silico modeling of canine muscle demonstrated that hyperoxia does not accelerate the dynamics of diffusion and muscle oxygen uptake at contraction onset.
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