Key result
Simulations predict neither convective nor diffusive oxygen delivery limits muscle Vo2 kinetics under normal conditions.
Population
Computational model validated using previously published experimental data from isolated canine…
Comparison
Computational modeling of slowed blood flow… vs Normal spontaneous conditions
Design
Preclinical
Authors
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Model isolates diffusion's role in muscle Vo2 kinetics; leaves open in vivo validation and clinical translation.
Computational modeling suggests that under normal conditions, neither convective nor diffusive oxygen delivery limits Vo2 kinetics in skeletal muscle during transition to moderate exercise.
Spires et al. (2013) studied Oxygen uptake (Vo2) kinetics in contracting skeletal muscle. Computational model of convective and diffusive O2 delivery was evaluated on Mean response time of Vo2 and relationship between diffusive conductance (PS) and blood flow (Q). Simulations predicted that neither oxygen convective nor diffusive delivery limit Vo2 kinetics in isolated canine muscle under normal conditions during transitions to moderate energy demand.
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