Key result
Oxygen uptake kinetics remained slowed when contractions were initiated from a raised metabolic rate (24 ± 6 s vs 12 ± 4 s; P<0.001) despite uniform muscle stimulation and increased oxygen delivery.
Population
9 anaesthetised, ventilated dogs (gastrocnemius complex isolated)
Comparison
Pump-perfusion to increase O2 delivery during… vs Intact circulation during the same contraction…
Design
Preclinical
Authors
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May limit exercise tolerance from elevated baselines; leaves open translation to human physiology.
p-value: p=<0.001
Skeletal muscle oxygen uptake kinetics remain slowed when contractions are initiated from a raised metabolic rate, independent of blood flow or recruitment dynamics.
Wüst et al. (2014) studied this question. Pump-perfusion with increased oxygen delivery vs. Spontaneous circulation was evaluated on Oxygen uptake kinetics (τ/TTI) (p=<0.001). Oxygen uptake kinetics remained slowed when contractions were initiated from a raised metabolic rate (24 ± 6 s vs 12 ± 4 s; P<0.001) despite uniform muscle stimulation and increased oxygen delivery.
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