Supplementary Figure S4 from Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy
Key Points
Zotatifin treatment significantly sensitizes DLBCL cells to ferroptosis, enhancing the potential effectiveness of CAR T-cell immunotherapy.
Key markers for apoptosis and ferroptosis were analyzed using immunoblotting, indicating critical molecular interactions.
The combination treatment of zotatifin with RSL3 or DMF demonstrates a stronger therapeutic effect in DLBCL cells.
This approach highlights the significance of targeting cap-dependent initiation to improve immunotherapeutic strategies.
Abstract
Immunoblot analysis of apoptosis and ferroptosis markers in DLBCL cells treated with zotatifin in combination with RSL3 or DMF.
Supplementary Figure S4 from Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy | Synapse
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2Supplementary Figure S3 from Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy2025