Mp75-11 Lower Urinary Tract Symptoms and Coronary Heart Disease Risk Among Participants of the Reasons for Geographic and Racial Differences in Stroke (Regards) Cohort Study

You have accessJournal of UrologyUrodynamics/Lower Urinary Tract Dysfunction/Female Pelvic Medicine: Non-neurogenic Voiding Dysfunction (Excluding OAB) (MP75)1 May 2024MP75-11 LOWER URINARY TRACT SYMPTOMS AND CORONARY HEART DISEASE RISK AMONG PARTICIPANTS OF THE REASONS FOR GEOGRAPHIC AND RACIAL DIFFERENCES IN STROKE (REGARDS) COHORT STUDY Alayne D. Markland, Kathryn L. Burgio, Belinda Williams, Richard Kennedy, Sara Elgayar, Yue Zhang, and Virginia J. Howard Alayne D. MarklandAlayne D. Markland , Kathryn L. BurgioKathryn L. Burgio , Belinda WilliamsBelinda Williams , Richard KennedyRichard Kennedy , Sara ElgayarSara Elgayar , Yue ZhangYue Zhang , and Virginia J. HowardVirginia J. Howard View All Author Informationhttps://doi.org/10.1097/01.JU.0001008676.21744.5f.11AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Known associations exist for coronary heart disease (CHD) and lower urinary tract symptoms (LUTS), with more cross-sectional evidence that LUTS are associated with CHD among men than women. However, less is known about the risk of having a CHD event among adults with LUTS. We examined the distribution of LUTS and the estimated risk of having a CHD event by sex among participants in the REasons for Geographic And Racial Differences in Stroke (REGARDS) study. METHODS: REGARDS is a national, longitudinal cohort study of 30,239 Black and White adults aged 45+ years, recruited in 2003-2007 with assessments for CHD risk factors, and repeated in 2013-2016. We analyzed data from a subsample of 6062 women and 4438 men who answered validated LUTS questionnaires (ICIQ-Female-LUTS and Male-LUTS; range 0-28) in 2019-2020. CHD risk was assessed using the Framingham CHD 10-year risk score, which includes measurement of age, sex, systolic blood pressure, total cholesterol, high density lipoprotein, diabetes, and smoking. We dichotomized LUTS as none/very mild (score 0-3) or mild/moderate/severe (score 4-28). After excluding participants with prevalent CHD, we analyzed 2,833 women and 1,604 men for the association of LUTS with 10-year CHD risk scores (beta coefficients and 95% confidence intervals). We performed separate multivariable linear regression models for women and men at risk for CHD adjusting for sociodemographic variables (age, race, education, and urban-rural setting) and body mass index (BMI). RESULTS: Overall, 70% of women reported LUTS (mean age 61.9±7.8 years, 41% Black, 59% White) and 62% of men reported LUTS (mean age 62.8±7.3 years, 29% Black, 71% White). After adjustment for sociodemographics and BMI, the risk of CHD in women with LUTS was beta 6.03, 95% CI -8.26, 20.31, p=0.40 and the risk of CHD in men was beta 0.06, 95% CI -13.68, 13.79, p>0.90. CONCLUSIONS: Older women and men have similarly high prevalence of LUTS. After removing women and men with prevalent CHD from the analysis, older women and men with LUTS did not have an increased 10-year risk of having CHD. Source of Funding: K24 AG073586 (PI: Markland) © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e1236 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Alayne D. Markland More articles by this author Kathryn L. Burgio More articles by this author Belinda Williams More articles by this author Richard Kennedy More articles by this author Sara Elgayar More articles by this author Yue Zhang More articles by this author Virginia J. Howard More articles by this author Expand All Advertisement PDF downloadLoading ...