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August 6, 2025Endocrinology and MetabolismOpen Access

Reduced Sphingosine-1-Phosphate Levels Exacerbate Type 2 Diabetes Mellitus and Associated Complications in a High-Fat Diet Mouse Model

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Authors

SHShih‐Chang HsuEnergy InstituteCCChing-Lu ChenTaipei Medical University HospitalCLChung-Te Liu

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Overview

Mice with reduced sphingosine-1-phosphate exhibited worsened insulin resistance and diabetes complications, suggesting potential therapeutic targets.

Key Points

  • S1PLC317A KI mice showed greater body weight and insulin resistance than wild-type mice on a high-fat diet.
  • Increased blood glucose levels and hepatic fat deposition were observed in the S1PLC317A KI mouse models.
  • Analysis revealed 4,656 differentially expressed genes enriched in pathways related to diabetes and bioenergetics.
  • Targeting sphingosine-1-phosphate pathways may provide new strategies for treating type 2 diabetes and its complications.

Cite This Study

Hsu et al. (2025) studied this question.

synapsesocial.com/papers/689521d79f4f1c896c427a35https://doi.org/10.3803/enm.2025.2360
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