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August 7, 2025Biomarkers in Medicine

Diagnostic value of lnc-RNAs TINCR, GC1 and AFAP1-AS1 in gastric cancer differentiation from healthy people

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Authors

PPPouneh PourfarzamMKMohammad Bagher Khadem‐ErfanRSRamin Shakeri

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Overview

Retrospective analysis reveals lncRNAs identify gastric cancer with notable specificity and sensitivity.

Key Points

  • Core finding shows specific lncRNAs have potential as biomarkers for diagnosing gastric cancer.
  • Significant changes in CEA and CA19.9 levels were found in patients compared to healthy controls.
  • Study involved 256 participants, with diagnostic assessment through ROC curve analysis of lncRNAs.
  • Identifying dysregulated lncRNAs can improve noninvasive diagnostic methods for gastric cancer.

Cite This Study

Pourfarzam et al. (2025) studied this question.

synapsesocial.com/papers/689521f09f4f1c896c42879ehttps://doi.org/10.1080/17520363.2025.2542112
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1lncRNAs ITFG2-AS1 and MMP25-AS1 have significant high-expression in gastric cancer patients as the potential diagnostic biomarkers: integrated bioinformatics and experimental investigation2024
  2. 2Genome-wide investigation of lncRNAs revealed their tight association with gastric cancer2024 · 4 citations
  3. 3Diagnostic Value of Circulating Long Non-Coding RNAs HOTAIR, NEAT1, and CCAT1 for Colorectal Cancer: A Vietnamese Case–Control Study2026
  4. 4Identification of plasma exosomal lncRNA as a biomarker for early diagnosis of gastric cancer2024
  5. 5Competing Endogenous RNA Networks Reveal Long Non-coding RNAs as Potential Prognostic Biomarkers in Gastric Cancer: A Systematic Review and Meta-Analysis2025