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August 5, 2025Frontiers in MicrobiologyOpen Access

Phylogenomic analysis of OXA-23-positive and genetic context of rare NDM-1-producing carbapenem-resistant Acinetobacter baumannii isolates in a teaching hospital in China

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Authors

SDSu Dong‪L‪Jiale LouCMCaiping Mao

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Overview

Phylogenomic analysis reveals genetic links between NDM-1-producing strains and OXA-23 producers in hospital, highlighting potential outbreak risks.

Key Points

  • The study identified 18 carbapenem-resistant Acinetobacter baumannii strains from patients in a Chinese teaching hospital.
  • All strains were genetically analyzed using whole-genome sequencing and identified 16 strains as OXA-23 producers.
  • Most isolates (61.11%) were from the intensive care unit, indicating a high-risk environment for outbreaks.
  • Genetic analysis suggests close relatedness among strains, emphasizing the need for enhanced surveillance in hospital settings.

Cite This Study

Dong et al. (2025) studied this question.

synapsesocial.com/papers/689521fa9f4f1c896c428c7ahttps://doi.org/10.3389/fmicb.2025.1575257
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