Unveiling Xuanshen decoction: A novel approach to combat slow transit constipation

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Xuanshen decoction effectively alleviates slow transit constipation symptoms in rats.
Increased levels of stem cell factor and phosphoinositide 3-kinase pathway components were noted in treated rats.
Histopathology revealed changes in colonic mucosa associated with mucin production due to treatment.
Findings indicate potential pathways for therapeutic intervention against oxidative stress and apoptosis in constipation.

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Combination of molecular docking and network pharmacology suggests Xuanshen decoction may reduce symptoms of slow transit constipation.

Zeng et al. (2025) studied this question.

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