What question did this study set out to answer?

This research aims to understand how Jichuan decoction (JCD) improves slow-transit constipation (STC) by affecting gut microbiota and neuromuscular function.

June 19, 2026Open Access

Therapeutic efficacy of Jichuan decoction (济川煎) in slow-transit constipation: focus on gut microbiota modulation

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This research aims to understand how Jichuan decoction (JCD) improves slow-transit constipation (STC) by affecting gut microbiota and neuromuscular function.
Induced STC in mice with diphenoxylate for 14 days.
Evaluated intestinal motility, neurotransmitter levels, and neural markers using various assays.
Analyzed gut microbiota via 16S rRNA sequencing.
JCD improved intestinal motility in STC mice and raised colonic neurotransmitter levels.
Increased mucosal thickness and goblet cell density, and altered key protein levels.
JCD reversed dysbiosis by enriching Akkermansia muciniphila.

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Implication

Randomized trial examines Jichuan decoction's impact on gut health and motility in slow-transit constipation, suggesting therapeutic potential.

Cite This Study

WANG et al. (2026) studied this question.

synapsesocial.com/papers/6a34de1265a5b0777af2da0b https://doi.org/10.19852/j.cnki.jtcm.2026.03.002

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Implication

Randomized trial examines Jichuan decoction's impact on gut health and motility in slow-transit constipation, suggesting therapeutic potential.

Therapeutic efficacy of Jichuan decoction (济川煎) in slow-transit constipation: focus on gut microbiota modulation

Key Points

Discussion

Implication

Cite This Study

Therapeutic efficacy of Jichuan decoction (济川煎) in slow-transit constipation: focus on gut microbiota modulation

Key Points

Discussion

Implication

Cite This Study

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