What question did this study set out to answer?

The primary aim is to investigate the therapeutic mechanisms of Zingiber mioga in treating slow transit constipation using metabolomic and metagenomic approaches.

March 2, 2026Frontiers in MicrobiologyOpen Access

Based on untargeted metabolomics and metagenomics: a study on the mechanism of Miao ethnomedicine Zingiber mioga (Thunb.) Rosc. in treating slow transit constipation

View Full Paper

Ask AI

Bookmark

Authors

YDYutao DuGuiyang College of Traditional Chinese Medicine LCLe Min ChenGuiyang College of Traditional Chinese Medicine XZXia ZhangGuiyang College of Traditional Chinese Medicine

Discussion

Member takes

Implication

Integrated analyses reveal Zingiber mioga improves gastrointestinal motility in a rat model of slow transit constipation, indicating its therapeutic potential.

Key Points

The primary aim is to investigate the therapeutic mechanisms of Zingiber mioga in treating slow transit constipation using metabolomic and metagenomic approaches.
Established a rat slow transit constipation model using intragastric loperamide hydrochloride.
Divided rats into six groups for treatment comparisons, including different doses of Zingiber mioga.
Quantified key gastrointestinal motility regulators in serum and evaluated colonic damage histopathologically.
Conducted untargeted metabolomic and fecal metagenomic analyses to identify differential metabolites and microbiota changes.
Zingiber mioga significantly reduced serum SP and increased MTL/GAS levels, promoting intestinal motility.
It ameliorated colonic lesions in a dose-dependent manner and improved the intestinal propulsive rate.
Identified 15 differential metabolites linked to nitrogen and amino acid metabolism.
Restored the Eubacteriales/Lachnospirales ratio and increased beneficial gut genera, such as Ruminococcus sp.

Cite This Study

Du et al. (2026) studied this question.

synapsesocial.com/papers/69a528b3f1e85e5c73bf03b0 https://doi.org/10.3389/fmicb.2026.1751739

View Full Paper

Ask AI

Bookmark

Implication

Integrated analyses reveal Zingiber mioga improves gastrointestinal motility in a rat model of slow transit constipation, indicating its therapeutic potential.

Based on untargeted metabolomics and metagenomics: a study on the mechanism of Miao ethnomedicine Zingiber mioga (Thunb.) Rosc. in treating slow transit constipation

Discussion

Member takes

Implication

Key Points

Cite This Study

Based on untargeted metabolomics and metagenomics: a study on the mechanism of Miao ethnomedicine Zingiber mioga (Thunb.) Rosc. in treating slow transit constipation

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider