What question did this study set out to answer?

The research aims to explore the effectiveness and mechanisms of Tiaozang Shumi Mixture in treating chronic constipation.

Mechanistic Insights into the Therapeutic Effects of Tiaozang Shumi Mixture on Chronic Constipation

View Full Paper

Ask AI

Bookmark

Authors

Investigates the therapeutic effects of Tiaozang Shumi Mixture on chronic constipation, suggesting potential mechanisms for treatment.

The research aims to explore the effectiveness and mechanisms of Tiaozang Shumi Mixture in treating chronic constipation.
Utilized network pharmacology to identify active compounds and targets from Tiaozang Shumi Mixture.
Conducted gene ontology and KEGG enrichment analyses to assess potential targets.
Performed animal studies with C57 mice to evaluate the therapeutic effects of different dosages of the mixture.
Identified 151 active compounds and 924 potential targets, leading to six core therapeutic targets.
Significantly improved defecation frequency and small intestinal propulsion in comparison to the model group.
Altered levels of 5-HT, VIP, NO, and AQP3, indicating potential mechanisms of action.

Fan et al. (2026) studied this question.

View Full Paper

Ask AI

Bookmark