Immunoglobulin A (IgA) nephropathy is the most common form of chronic glomerulonephritis and one of the leading causes of end-stage renal disease. Currently, the ability to accurately predict the risk of this progression at the individual patient level is limited. This paper analyzes the scientific literature containing research results focused on identifying independent predictors of IgA nephropathy progression risk. According to most studies, variables such as proteinuria, arterial hypertension, and baseline kidney function have a stable and independent association with worse kidney prognosis. Histological changes in kidney biopsy serve as independent predictors. The combination of morphologic and clinical data improves predictive accuracy. To enhance treatment outcomes and long-term prognosis, further research is necessary, including the search for new biomarkers and the development of a universally accepted risk stratification system.
Korabelnikov et al. (Wed,) studied this question.