What question did this study set out to answer?

To systematically review the progression of IgA nephropathy from its molecular pathogenesis to end-stage kidney disease and evaluate risk-stratified management strategies.

August 14, 2026Clinical Nephrology

Mechanisms and management of IgA nephropathy progression to end-stage renal disease: From the “four-hit” theory to precision medicine

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To systematically review the progression of IgA nephropathy from its molecular pathogenesis to end-stage kidney disease and evaluate risk-stratified management strategies.
Conducted a systematic literature review synthesizing evidence on IgA nephropathy pathogenesis, pathological risk indicators, and pharmacotherapies.
Disease progression is driven by a 'four-hit' pathogenic mechanism amplified by complement activation, with persistent proteinuria, hypertension, and tubular atrophy/interstitial fibrosis acting as major risk predictors.
Renin-angiotensin system inhibitors and SGLT2 inhibitors form the foundation of supportive treatment, while glucocorticoids and novel targeted agents provide options for patients with persistent high-risk progression.

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Implication

Systematic review demonstrates mechanisms of progression and targeted therapies in IgA nephropathy, highlighting precision medicine strategies to prevent end-stage kidney disease.

Cite This Study

Zhou et al. (2026) studied this question.

synapsesocial.com/papers/6a7ec775b70b84ec8b913e76 https://doi.org/10.5414/cn112027

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Implication

Systematic review demonstrates mechanisms of progression and targeted therapies in IgA nephropathy, highlighting precision medicine strategies to prevent end-stage kidney disease.

Mechanisms and management of IgA nephropathy progression to end-stage renal disease: From the “four-hit” theory to precision medicine

Key Points

Discussion

Implication

Cite This Study

Mechanisms and management of IgA nephropathy progression to end-stage renal disease: From the “four-hit” theory to precision medicine

Key Points

Discussion

Implication

Cite This Study

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