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The review explores the mechanisms, risk stratification, and therapeutic approaches for IgA nephropathy.

April 25, 2026DiagnosticsOpen Access

IgA Nephropathy: Mechanisms, Risk Stratification, and Precision Therapy

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The review explores the mechanisms, risk stratification, and therapeutic approaches for IgA nephropathy.
Narrative review linking multi-hit model to current management and emerging therapies
Assessment focusing on proteinuria and glomerular filtration rate trajectories
Discussion of immunomodulatory strategies for high-risk patients with persistent proteinuria
Current management focuses on reducing proteinuria and protecting kidney function through optimized supportive care
Emerging therapies target specific molecular pathways, including the BAFF/APRIL axis and complement pathways
Significant gaps noted in long-term data and evidence for specific populations.

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Narrative review examines IgA nephropathy management and emerging therapies, highlighting implementation gaps.

Sami Alobaidi (2026) studied this question.

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