Incorporation of Metabolic Dysfunction‐Associated Steatotic Liver Disease in the Health Stage of Cardiovascular‐Kidney‐Metabolic Syndrome Improves Predictive Ability for Coronary Artery Disease in a Japanese General Population

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Analysis shows modified CKM syndrome stages improve CAD risk stratification in a Japanese population, suggesting better management strategies.

The modified health stage classification incorporating MASLD enhanced CAD risk prediction accuracy.
Kaplan–Meier analysis indicated improved risk stratification compared to the original health stages.
Cox proportional hazards analysis showed significant hazard ratios in both original and modified stages.
Machine learning identified MASLD as a crucial predictor of CAD, demonstrating its importance in risk models.

Kawaharata et al. (2025) studied this question.

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Analysis shows modified CKM syndrome stages improve CAD risk stratification in a Japanese population, suggesting better management strategies.