August 7, 2025

Temporal drift of sleep-wake representations in hypothalamic neuronal ensembles

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Longitudinal imaging reveals dynamic shifts in neuronal activity across sleep-wake states, suggesting reorganization of hypothalamic neurons.

Hypothalamic neurons do not maintain stable activity patterns during sleep-wake states.
Longitudinal calcium imaging was used to observe activity in freely-moving sleeping mice.
Sleep deprivation had minimal effects on neuronal activity selectivity across sleep-wake states.
The sleep-promoting drug diazepam activated previously inactive neurons, highlighting dynamic shifts.

Adamantidis et al. (2025) studied this question.

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Longitudinal imaging reveals dynamic shifts in neuronal activity across sleep-wake states, suggesting reorganization of hypothalamic neurons.