July 13, 2025Open Access

Cellular basis for cortical network aging in primates

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Cortical networks show age-related changes linked to cell type composition in macaques.
Infragranular neurons and oligodendrocytes significantly correlate with network similarities as the brain ages.
Transmodal networks experience marked declines in strength, particularly in default mode and limbic regions.
Findings highlight the importance of integrating imaging and transcriptomics to study brain aging.

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Research uncovers how aging affects cortical networks in macaques, suggesting implications for understanding brain health.

Tsotras et al. (2025) studied this question.

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