Mechanistic studies reveal that iridium complexes improve asymmetric hydrogenation, indicating a pathway involving direct alkene hydrogenation.
A novel class of well-defined rhodium and iridium complexes containing various chiral cyclic(alkyl)(amino)carbene (ChiCAAC) ligands has been synthesised and fully characterized. While no enantioselectivity was observed with chiral Rh-CAAC, the Ir-CAAC counterparts demonstrated good performances in the asymmetric hydrogenation of various allylic alcohols and derivatives with up to 86% ee. Mechanistic studies, including deuteration experiments revealed that the reduction proceeds via direct alkene hydrogenation rather than via isomerization.
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Morvan et al. (2025) studied this question.
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