New catalysts demonstrate improved enantioselectivity in asymmetric hydrogenation, suggesting potential in synthetic applications.
A novel class of well‐defined rhodium and iridium complexes containing various chiral cyclic(alkyl)(amino)carbene ( Chi CAAC) ligands has been synthesized and fully characterized. While no enantioselectivity is observed with chiral Rh‐CAAC, the Ir‐CAAC counterparts demonstrate good performances in the asymmetric hydrogenation of various allylic alcohols and derivatives with up to 86% ee. Mechanistic studies, including deuteration experiments, reveal that the reduction proceeds via direct alkene hydrogenation rather than via isomerization.
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Morvan et al. (2025) studied this question.
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