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July 14, 2025

Exploring the underlying mechanisms of Hedyotis diffusa and Scutellaria barbata herb pair on the prognosis and treatment efficacy of bladder cancer patients: an integrated approach of network pharmacology and bioinformatics analysis

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Authors

YLYuan LiuLDLei DuanMZMengwei Zhu

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Overview

Integration of network pharmacology and bioinformatics reveals HD-SB influences treatment efficacy and prognostic markers in bladder cancer patients, suggesting novel therapeutic targets.

Key Points

  • Hedyotis diffusa and Scutellaria barbata share 497 common targets impacting bladder cancer treatment.
  • A 15-gene prognostic signature was identified, correlating with patient survival outcomes.
  • Methods included network pharmacology and scRNA-seq to explore relationships with immune cells and checkpoints.
  • HD-SB demonstrated the ability to inhibit bladder cancer cell viability and migration in vitro.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/689a02afe6551bb0af8cc08chttps://doi.org/10.21203/rs.3.rs-6732285/v1
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