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July 1, 2021International Journal of General MedicineOpen Access

AURKB, CHEK1 and NEK2 as the Potential Target Proteins of Scutellaria barbata on Hepatocellular Carcinoma: An Integrated Bioinformatics Analysis

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Authors

CHChaoyuan HuangGuangdong Provincial Hospital of Traditional Chinese MedicineHLHu LuoFudan UniversityYHYuancheng HuangGuangzhou Electronic Technology (China)

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Implication

Randomized trial identifies AURKB, CHEK1, and NEK2 as key proteins for Scutellaria barbata's anti-HCC effect, suggesting new treatment avenues.

Key Points

  • This study explores the anti-HCC mechanism of Scutellaria barbata using integrated bioinformatics analysis.
  • Active ingredients and targets of Scutellaria barbata were identified using TCMSP, PubChem, and SwissTargetPrediction databases.
  • HCC disease targets were identified from GEO dataset using WGCNA.
  • PPI networks were constructed and analyzed using Cytoscape, followed by GO and KEGG analyses.
  • Sixteen active components from Scutellaria barbata were selected for investigation.
  • A total of 442 component targets were identified, leading to 21 common genes and 10 critical targets for analysis.
  • Enrichment analysis revealed involvement of cell cycle, DNA replication, and p53 signaling pathways.

Cite This Study

Huang et al. (2021) studied this question.

synapsesocial.com/papers/6a623a37437918011ec92fd7https://doi.org/10.2147/ijgm.s318077
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