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July 14, 2025

Dynamic change and spatial distribution of HIV-1 CRF119₀107 transmission clusters from 2019 to 2024 in Nanjing, China: a genomic and spatial epidemiological analysis

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Authors

YXYuanyuan XuHSHongjie ShiXLXin Li

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Overview

Genomic and spatial epidemiological analysis reveals high drug resistance in HIV-1 clusters, indicating urgent intervention needs.

Key Points

  • The study found a high TDR prevalence of 15.9% among individuals infected with HIV-1 CRF119_0107.
  • Fifty-six percent of sequences clustered, highlighting significant transmission links among MSM.
  • Spatial analysis showed extensive inter-district transmission with strong linkages even in non-adjacent areas.
  • The approach supports real-time surveillance and targeted interventions in high-growth HIV-1 clusters.

Cite This Study

Xu et al. (2025) studied this question.

synapsesocial.com/papers/689a02b6e6551bb0af8cc1f3https://doi.org/10.21203/rs.3.rs-6539216/v1
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  1. 1The prevalence, temporal trends, and geographical distribution of HIV-1 subtypes among men who have sex with men in China: A systematic review and meta-analysis2019 · 48 citations
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  3. 3Natural presence of the V179D and K103R/V179D mutations associated with resistance to nonnucleoside reverse transcriptase inhibitors in HIV-1 CRF65_cpx strains2020 · 13 citations
  4. 4Transmitted drug resistance and transmission clusters among ART-naïve HIV-1-infected individuals from 2019 to 2021 in Nanjing, China2023 · 16 citations