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July 14, 2025Current Issues in Molecular BiologyOpen Access

The Antidiabetic Mechanisms of Cinnamon Extract: Insights from Network Pharmacology, Gut Microbiota, and Metabolites

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Authors

RWRong WangKYKuan YangXLXuefeng Liu

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Overview

Network pharmacology identifies 471 targets in type 2 diabetes, suggesting cinnamon impacts gut microbiota.

Key Points

  • Cinnamon extract shows potential in treating type 2 diabetes by improving glucose and lipid metabolism.
  • In vivo studies indicated cinnamon alleviates hyperglycemia and insulin resistance and alters gut microbiota composition.
  • Chemical profiling identified 32 active ingredients, including quercetin, and highlighted key metabolic pathways involved.
  • Cinnamon enhances gut barrier function and reduces proinflammatory cytokines, indicating its therapeutic relevance.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/689a02b6e6551bb0af8cc2cbhttps://doi.org/10.3390/cimb47070543
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cinnamon as a Multitarget Anti-Diabetic Phytotherapy: Phytochemical Profiling, Mechanistic Interaction, and Clinical Trials2026
  2. 2Cinnamon as a Natural Modulator of Metabolic Health: A Review of Contemporary Research2025
  3. 3Cinnamon-Derived Phytonutrients as Modulators of Ion Channels and G Protein-Coupled Receptor Signaling in Metabolic Diseases2026 · 7 citations
  4. 4Antidiabetic effects of cinnamon (Cinnamomum sp.) and the influence of the compounds it contains2025
  5. 5HARNESSING CINNAMON FOR HORMONAL BALANCE: THERAPEUTIC INSIGHTS IN ENDOCRINE DISORDERS2026