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July 14, 2025Molecular and Cellular BiochemistryOpen Access

Unlocking cardiac health: exploring the role of class I HDACs in cardiovascular diseases

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Authors

PPPadmini PaiRDRachel Savio D'MelloOBOjasvi Mangesh Brahme

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Overview

This review demonstrates how hdacs regulate gene expression in cardiovascular disease, suggesting new therapeutic approaches.

Key Points

  • Class I hdacs are crucial in regulating gene expression related to cardiovascular disease.
  • Aberrant hdac activity is linked to various pathological processes such as inflammation and fibrosis in cvd.
  • Preclinical and clinical studies highlight the potential of hdac inhibitors as effective therapies for cardiovascular health.
  • Investigating isoform-specific roles of hdacs may lead to targeted interventions for treating cardiovascular disease.

Cite This Study

Pai et al. (2025) studied this question.

synapsesocial.com/papers/689a02b6e6551bb0af8cc397https://doi.org/10.1007/s11010-025-05353-5
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1HDACs and Their Inhibitors on Post-Translational Modifications: The Regulation of Cardiovascular Disease2025 · 12 citations
  2. 2Histone deacetylase 4: A therapeutic target for cardiovascular diseases (Review)2025 · 2 citations
  3. 3Targeting histone deacetylases for heart failure2009 · 42 citations
  4. 4HDACs in the Brain: From Chromatin Remodeling to Neurodegenerative Disease2025 · 17 citations
  5. 5Histone deacetylase 6 as a novel promising target to treat cardiovascular disease2024 · 4 citations