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July 14, 2025

Quantifying Immune Checkpoint engagement in Patient Biopsies

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Authors

CNClaudia NavasLCL.M. CamachoJAJ.M. Ferrer Agüero

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Overview

Quantitative profiling identifies biomarkers linking immune checkpoint blockade effectiveness and patient outcomes, suggesting more tailored immunotherapy.

Key Points

  • Main finding shows that current biomarkers like PD-L1 TPS score are inadequate for patient stratification.
  • Strong evidence indicates that a quantitative spatial proteomics approach could enhance understanding of immune interactions in tumours.
  • The analysis involved assessing immune checkpoints in patient tissue samples to determine their functional state.
  • Significance lies in the potential for improved immunotherapy strategies by targeting specific patient needs based on immune profiling.

Cite This Study

Navas et al. (2025) studied this question.

synapsesocial.com/papers/689a02b6e6551bb0af8cc42dhttps://doi.org/10.1101/2025.07.04.25330865
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  4. 4The Search for Predictive Biomarkers in Response to Immune Checkpoint Inhibitors and Associated Adverse Events2025 · 1 citations
  5. 5Multiomic immune microenvironment signatures associated with response and resistance to immune checkpoint blockade across solid tumours2026