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July 15, 2025Open Access

Early transcriptional divergence underlies cell fate bias in bovine embryos

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Authors

SSSatoshi SugimuraHKH. KoyamaDMDaisuke Mashiko

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Overview

Single-cell RNA sequencing shows transcriptional asymmetry in bovine embryos, suggesting developmental plasticity may be lost.

Key Points

  • Transcriptional divergence in bovine embryos begins as early as the 4-cell stage, affecting cell fates.
  • Single-cell RNA sequencing revealed variability in gene expression, particularly among MAPK pathway genes.
  • Larger blastomeres are more likely to form cavities, indicating a potential trophectoderm fate.
  • The study highlights the importance of both molecular and physical asymmetries in early embryonic development.

Cite This Study

Sugimura et al. (2025) studied this question.

synapsesocial.com/papers/689a02b6e6551bb0af8cc48ehttps://doi.org/10.21203/rs.3.rs-7028131/v1
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Also Consider

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  1. 1Single‐cell RNA‐Seq reveals the earliest lineage specification and X chromosome dosage compensation in bovine preimplantation embryos2024 · 10 citations
  2. 2Proteome asymmetry in mouse and human embryos before fate specification2024 · 2 citations
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  4. 4Sex-biased transcriptome in in vitro produced bovine early embryos2025 · 3 citations
  5. 5Developmental Morphokinetics and the Transcriptomic Profile of Bovine First-Cleaved Embryos: Normal vs. Abnormal Divisions2026