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September 5, 2025Cell & BioscienceOpen Access

Sex-biased transcriptome in in vitro produced bovine early embryos

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Authors

MSMeihong ShiCornell UniversityGLGuangsheng LiCornell UniversityHAHelena AraujoUniversidade Federal do Rio de Janeiro

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Overview

Analysis reveals significant transcriptomic differences in early bovine embryos, indicating distinct metabolic pathways and alternative splicing based on sex.

Key Points

  • Male bovine blastocysts show significantly faster development compared to female embryos, indicating a crucial sex bias.
  • Ultra-low input RNA-seq uncovered 837 differentially expressed genes, with 231 upregulated in males and 606 downregulated in females.
  • Male-biased gene expression is associated with energy metabolism, while female-biased genes relate to sex differentiation and inflammatory pathways.
  • This work highlights the role of alternative splicing in sex-specific regulations, with implications for understanding embryonic development processes.

Cite This Study

Shi et al. (2025) studied this question.

synapsesocial.com/papers/68bb3a352b87ece8dc954d63https://doi.org/10.1186/s13578-025-01459-x
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