July 15, 2025

Longitudinal adipose tissue single cell transcriptomics reveals genes and variants regulating weight loss after bariatric surgery

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Authors

SLSeung Hyuk LeeUniversity of California, Los Angeles AKAsha KarUniversity of California, Los Angeles SHSini HeinonenUniversity of Helsinki

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Implication

Longitudinal analysis reveals significant weight loss genes and variants in individuals post bariatric surgery, suggesting genetic influence on outcomes.

Key Points

Weight loss after bariatric surgery varies significantly among individuals due to genetic factors.
Longitudinal transcriptomics of adipose tissue identified crucial weight loss genes related to adipocyte function.
A polygenic risk score based on adipocyte gene variants significantly predicts the extent of weight loss achieved.
The findings contribute to understanding genetic regulation of weight loss, enhancing personalized obesity treatment strategies.

Cite This Study

Lee et al. (2025) studied this question.

synapsesocial.com/papers/689a02b6e6551bb0af8cc536 https://doi.org/10.1101/2025.07.11.25331390

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Implication

Longitudinal analysis reveals significant weight loss genes and variants in individuals post bariatric surgery, suggesting genetic influence on outcomes.

Longitudinal adipose tissue single cell transcriptomics reveals genes and variants regulating weight loss after bariatric surgery

Discussion

Member takes

Implication

Key Points

Cite This Study

Longitudinal adipose tissue single cell transcriptomics reveals genes and variants regulating weight loss after bariatric surgery

Discussion

Member takes

Implication

Key Points

Cite This Study

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