July 15, 2025

Supplementary Figure 2 from The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer

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The integrated stress response influences the stability of mRNA and proteins in lung cancer.
Activation of the ISR pathway has a notable effect on translation efficiency of immune checkpoints.
Investigations utilized supplementary figures to clarify translational control processes.
Findings can advance understanding of immune checkpoint modulation in lung cancer treatment.

Implication

Supplementary figure highlights integration of translational control mechanisms affecting immune checkpoints in lung cancer.

Supplementary Figure 2 shows the effect of ISR pathway activation on protein and mRNA stability, and translation.

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Thomas-Jardin et al. (2025) studied this question.

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Supplementary figure highlights integration of translational control mechanisms affecting immune checkpoints in lung cancer.

Supplementary Figure 2 shows the effect of ISR pathway activation on protein and mRNA stability, and translation.