Supplementary figure shows FOXP4 influences gene expression and protein levels in esophageal cancer, highlighting its role in alcohol exposure effects.
Supplementary Figure S5 shows FOXP4 transcriptionally upregulates CYP26B1 and MYC. (A) The RNA level of FOXP4 in FOXP4-overexpressing KYSE30 and FOXP4-overexpressing KYSE150 cells. (B-C) The protein level of FOXP4 in ESCC cells with FOXP4 overexpression or knockdown. (C) The pathway enrichment analysis of genes regulated by FOXP4 in ESCC cells. (D) The expression of MYC was correlated with the expression of FOXP4 in esophageal mucosal tissues from the GTEx database. Shade represented 95% confidence intervals. (E) The H3K27ac CUT&Tag qPCR experiment results of FOXP4, CYP26B1, and MYC in alcohol-treated KYSE30 and KYSE150 cells. (F) The protein expression levels of FOXP4, CYP26B1 and MYC were higher in alcohol-treated KYSE30 and KYSE150 cells than the control.
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Niu et al. (2025) studied this question.
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