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July 15, 2025

Supplementary Figure S3 from Clinicopathologic Features, Molecular Landscape, and Prognostic Implications of Ovarian Low-grade Serous Tumors with Histologic Transformation

M. Herman Chui Eun-Young Kang Ryan Kahn Sarah Chiang Qin Zhou Alexia Iasonos Beryl Manning‐Geist Pier Selenica Arnaud Da Cruz Paula Kara Long Roche Britta Weigelt Rachel N. Grisham

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Key Points

Ovarian low-grade serous tumors can undergo histologic transformation to high-grade serous carcinoma.
Somatic BRCA2 mutations contribute to the development of high-grade serous carcinoma from low-grade origins.
TP53-wildtype status is significant in understanding tumor behavior and prognosis.
These findings suggest that monitoring histologic transformation could inform treatment strategies for affected patients.

Implication

Analysis uncovers histologic transformation in ovarian low-grade serous tumors, implying high-grade serous carcinoma's role in prognosis.

Abstract

TP53-wildtype high-grade serous carcinoma derived from low-grade serous carcinoma with underlying somatic BRCA2 mutation

Discussion

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Cite This Study

Chui et al. (2025) studied this question.

synapsesocial.com/papers/689a02bce6551bb0af8cc6b9 https://doi.org/10.1158/1078-0432.29568316

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S4 from Clinicopathologic Features, Molecular Landscape, and Prognostic Implications of Ovarian Low-grade Serous Tumors with Histologic Transformation2025
2Supplementary Figure S1 from Clinicopathologic Features, Molecular Landscape, and Prognostic Implications of Ovarian Low-grade Serous Tumors with Histologic Transformation2025
3Supplementary Figure S5 from Clinicopathologic Features, Molecular Landscape, and Prognostic Implications of Ovarian Low-grade Serous Tumors with Histologic Transformation2025
4Supplementary Figure S2 from Clinicopathologic Features, Molecular Landscape, and Prognostic Implications of Ovarian Low-grade Serous Tumors with Histologic Transformation2025
5Data from Clinicopathologic Features, Molecular Landscape, and Prognostic Implications of Ovarian Low-grade Serous Tumors with Histologic Transformation2025