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November 1, 2025American Journal of Clinical PathologyOpen Access

151 Ovarian High-Grade Serous Carcinoma associated with a Continuum of Borderline Tumor and Low-Grade Carcinoma Components in a Young Female with BRCA1 Germline Mutation: A Rare Association

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Authors

IKIsha KhanduriNPNinad M Patil

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Overview

Case report reveals p53 mutations and germline BRCA1 mutation in ovarian cancer, suggesting atypical tumor behavior in young females.

Key Points

  • To describe a rare case of ovarian high-grade serous carcinoma associated with borderline tumor and low-grade carcinoma components in a young female with BRCA1 mutation.
  • Case report of a 35-year-old female with an ovarian mass
  • Underwent left salpingo-oophorectomy
  • Microscopic examination of tumor patterns and IHC analysis
  • NGS for genetic profiling
  • Assessment of tumor markers
  • Mixed morphologic patterns including low-grade and high-grade nuclei
  • Presence of p53 mutation noted in both high-grade and borderline tumors
  • Germline BRCA1 mutation identified.

Cite This Study

Khanduri et al. (2025) studied this question.

synapsesocial.com/papers/6925436cc0ce034ddc35877bhttps://doi.org/10.1093/ajcp/aqaf121.178
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Seromucinous borderline tumor-associated high-grade ovarian cancers2024
  2. 2Abstract A107: Characterizing the genomic and immunologic landscape of serous borderline tumors and low-grade serous ovarian cancer2024
  3. 3The Histopathological Findings of High-grade Serous Ovarian Carcinomas in Patients with BRCA Germline Mutations, Single Center Experience2024 · 1 citations
  4. 4Dual TP53 mutations in ovarian high-grade serous carcinoma combined with squamous cell carcinoma: a case report and systematic literature review2026
  5. 5High-grade Anaplastic Transformation of Ovarian Serous Borderline Tumor2024 · 3 citations