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September 10, 2025CLINICAL AND EXPERIMENTAL MORPHOLOGYOpen Access

Clinical, morphological, and molecular-genetic features of ovarian serous borderline tumors

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Authors

АБАлина БадлаеваPirogov Russian National Research Medical UniversityATAnna TregubovaNational Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of the Ministry of Healthcare of the Russian FederationAAA.V. AsaturovaPirogov Russian National Research Medical University

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Overview

Analysis reveals MAPK mutations in ovarian serous borderline tumors, suggesting links to eosinophilic cells for prediction.

Key Points

  • Over half of the ovarian serous borderline tumors exhibited mutations in the MAPK signaling pathway, indicating underlying genetic factors.
  • Eosinophilic cells were associated with BRAF mutations, providing a pathway for identifying patients who may require genetic testing.
  • High Ki-67 levels (≥7%) correlated with an increased recurrence risk, emphasizing the importance of assessing proliferative activity.
  • No significant impact of sex steroid hormone receptor expression on disease-free survival was observed, suggesting different prognostic factors.

Cite This Study

Бадлаева et al. (2025) studied this question.

synapsesocial.com/papers/68c1b81854b1d3bfb60ec1d5https://doi.org/10.31088/cem2025.14.4.22-31
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract A107: Characterizing the genomic and immunologic landscape of serous borderline tumors and low-grade serous ovarian cancer2024
  2. 2Eosinophilic Cells in Ovarian Borderline Serous Tumors as a Predictor of BRAF Mutation2024 · 3 citations
  3. 3High-grade Anaplastic Transformation of Ovarian Serous Borderline Tumor2024 · 3 citations
  4. 4Seromucinous borderline ovarian tumors: Clinical and ultrasound characteristics and association with endometriosis2026
  5. 5151 Ovarian High-Grade Serous Carcinoma associated with a Continuum of Borderline Tumor and Low-Grade Carcinoma Components in a Young Female with BRCA1 Germline Mutation: A Rare Association2025