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July 15, 2025Open Access

A PKM2-YAP reciprocal repartitioning modulates invasion of breast cancer cells

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Authors

MBMallar BanerjeeMPMayank PandhariSMSudiksha Mishra

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Overview

Experiment shows PKM2 and YAP interactions modulate migration in breast cancer cells, suggesting new treatment strategies.

Key Points

  • PKM2 and YAP proteins play a critical role in cancer cell invasion and metabolism during metastasis.
  • Cancer cells exhibit different shapes and migration patterns depending on the stiffness of the surrounding environment.
  • Impairing or enhancing PKM2 activity impacts migration and energy metabolites like pyruvate and lactate.
  • Targeting the PKM2-YAP feedback loop may provide innovative approaches to breast cancer therapy.

Cite This Study

Banerjee et al. (2025) studied this question.

synapsesocial.com/papers/689a02bce6551bb0af8cc740https://doi.org/10.1101/2025.07.10.664113
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