July 16, 2025

A cross-disorder analysis of CNVs finds novel loci and dose-dependent relationships of genes to psychiatric traits

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Authors

OSOmar ShantaUniversity of California, San Diego MKMarieke KleinRadboud University Nijmegen MSM SacksUniversity of California, San Diego

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Implication

Genome-wide cnv analysis discovers novel loci in schizophrenia and dose-dependent gene effects on psychiatric conditions, indicating complex relationships.

Key Points

Core finding shows 35 genome-wide significant associations at 18 loci related to psychiatric conditions.
Identified novel associations particularly in schizophrenia and across multiple disorders during analysis.
Study involved 574,965 participants across six diagnostic categories using genome-wide cnv analysis.
Findings highlight the pleiotropic effects of genes, indicating both positive and negative influences on psychopathology.

Cite This Study

Shanta et al. (2025) studied this question.

synapsesocial.com/papers/689a02c9e6551bb0af8ccd63 https://doi.org/10.1101/2025.07.11.25331310

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Implication

Genome-wide cnv analysis discovers novel loci in schizophrenia and dose-dependent gene effects on psychiatric conditions, indicating complex relationships.

A cross-disorder analysis of CNVs finds novel loci and dose-dependent relationships of genes to psychiatric traits

Discussion

Member takes

Implication

Key Points

Cite This Study

A cross-disorder analysis of CNVs finds novel loci and dose-dependent relationships of genes to psychiatric traits

Discussion

Member takes

Implication

Key Points

Cite This Study

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