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This research demonstrates a novel method to measure lipophilicity in bisphosphonates, suggesting improved pharmaceutical assessments.
Bisphosphonates are pharmaceutical compounds commonly used in the treatment of osteoporosis, Paget’s disease, and multiple myeloma. Their lipophilicity was measured using a sensor array composed of poly(vinyl chloride) (PVC)-based ion-selective membranes (ISMs), modified with a polyaniline (PANI) layer that affects surface properties and acts as an anion-exchanger. The lipophilicity of bisphosphonates including ibandronate, clodronate, risedronate, and alendronate was analyzed both in standard and commercial samples. The influence of membrane composition (presence or absence of an anion-exchanger) and PANI deposition conditions (monomer form and/or salt content) on membrane surface properties (lipophilicity and signal stability) was investigated and confirmed using surface-wetting characterization, SEM-EDS mapping and potentiometry. Principal component analysis (PCA) enabled discrimination among the bisphosphonates based on lipophilicity and revealed distinct contributions of individual ISMs in both standard and commercial samples.
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Shishkanová et al. (2025) studied this question.
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