A novel approach for discriminating lipophilic bisphosphonate-based pharmaceuticals using a potentiometric array

Tatiana V. Shishkanová; Annemarie Skálová-Coufal; Jaroslav Otta; M. Člupek; Martin Vrňata

doi:10.1039/d5ay01639h

January 1, 2026Analytical MethodsOpen Access

A novel approach for discriminating lipophilic bisphosphonate-based pharmaceuticals using a potentiometric array

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Key Points

The research aims to develop a new method for measuring the lipophilicity of bisphosphonates using a sensor array.
Developed a potentiometric array with PVC-based ion-selective sensors.
Measured lipophilicity of bisphosphonate compounds using the sensor array.
Conducted analyses of various bisphosphonates relevant to osteoporosis and multiple myeloma.
Successfully discriminated between different bisphosphonates based on their lipophilicity.
Found a clear correlation between sensor response and lipophilicity levels in evaluated compounds.

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Implication

Novel approach discriminates lipophilic bisphosphonates in pharmaceuticals, indicating a new method for analysis.

Abstract

Bisphosphonates are pharmaceutical compounds commonly used in the treatment of osteoporosis, Paget’s disease, and multiple myeloma. Their lipophilicity was measured using a sensor array composed of poly(vinyl chloride) (PVC)-based ion-selective...

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Shishkanová et al. (2026) studied this question.

synapsesocial.com/papers/69843553f1d9ada3c1fb3f59 https://doi.org/10.1039/d5ay01639h

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A novel approach for discriminating lipophilic bisphosphonate-based pharmaceuticals using a potentiometric array

Key Points

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Implication

Abstract

Discussion

Cite This Study

A novel approach for discriminating lipophilic bisphosphonate-based pharmaceuticals using a potentiometric array

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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