July 21, 2025Open Access

A gene regulatory element modulates myosin expression and controls cardiomyocyte response to stress

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Authors

TATaylor AnglenDuke University IKIrene M. KaplowCarnegie Mellon University BCBaekgyu ChoiKorea Advanced Institute of Science and Technology

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Implication

Genome-wide profiling reveals that a gene regulatory element regulates myosin expression in cardiomyocytes, indicating its role in stress response mechanisms.

Key Points

MAIN FINDING: A specific gene regulatory element is essential for regulating myosin expression in cardiomyocytes.
KEY EVIDENCE: Activation of the enhancer prevents polyploidization and improves response to endothelin-1 stress.
APPROACH: The study utilizes genome-wide profiling and chromatin conformation assays with human pluripotent stem cells.
SIGNIFICANCE: These discoveries provide new insights into cardiac gene regulation and potential therapeutic avenues for heart disease.

Cite This Study

Anglen et al. (2025) studied this question.

synapsesocial.com/papers/689a060ee6551bb0af8cd1c2 https://doi.org/10.1101/2025.07.19.665672

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Implication

Genome-wide profiling reveals that a gene regulatory element regulates myosin expression in cardiomyocytes, indicating its role in stress response mechanisms.

A gene regulatory element modulates myosin expression and controls cardiomyocyte response to stress

Discussion

Member takes

Implication

Key Points

Cite This Study

A gene regulatory element modulates myosin expression and controls cardiomyocyte response to stress

Discussion

Member takes

Implication

Key Points

Cite This Study

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